Fiche publication
Date publication
octobre 2023
Journal
Biomechanics and modeling in mechanobiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ANSELME Karine
,
Dr PIEUCHOT Laurent
Tous les auteurs :
Manifacier I, Carlin G, Liu D, Vassaux M, Pieuchot L, Luchnikov V, Anselme K, Milan JL
Lien Pubmed
Résumé
In vitro experiments have shown that cell scale curvatures influence cell migration; cells avoid convex hills and settle in concave valleys. However, it is not known whether dynamic changes in curvature can guide cell migration. This study extends a previous in-silico model to explore the effects over time of changing the substrate curvature on cell migration guidance. By simulating a dynamic surface curvature using traveling wave patterns, we investigate the influence of wave height and speed, and find that long-distance cell migration guidance can be achieved on specific wave patterns. We propose a mechanistic explanation of what we call dynamic curvotaxis and highlight those cellular features that may be involved. Our results open a new area of study for understanding cell mobility in dynamic environments, from single-cell in vitro experiments to multi-cellular in vivo mechanisms.
Mots clés
Cell migration, Contractility, Curvature, Curvotaxis, Long-distance cell migration, Modeling, Nucleus
Référence
Biomech Model Mechanobiol. 2023 10 24;:
