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Date publication

septembre 2023

Journal

Photodiagnosis and photodynamic therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Dr COLLIN Bertrand , Dr DECREAU Richard , Dr BELLAYE Pierre-Simon


Tous les auteurs :
Lioret V, Bellaye PS, Bernhard Y, Moreau M, Guillemin M, Drouet C, Collin B, Decréau RA

Résumé

Old-generation photosensitizers are minimally used in current photodynamic therapy (PDT) because they absorb in the UV/blue/green region of the spectrum where biological tissues are generally highly absorbing. The UV/blue light of Cherenkov Radiation (CR) from nuclear disintegration of beta-emitter radionuclides shows promise as an internal light source to activate these photosensitizers within tissue. Outline of the study: 1) radionuclide choice and Cherenkov Radiation, 2) Photosensitizer choice, synthesis and radiolabeling, 3) CR-induced fluorescence, 4) Verification of ROS formation, 5) CR-induced PDT with either free eosine and free CR emitter, or with radiolabelled eosin.

Mots clés

Cherenkov Radiation Energy Transfer (CRET), Cherenkov Radiation induced Photodynamic Therapy (CR-PDT), Eosin, Eosin-DOTAGA, Fluorescence, Radiolabeling, Radionuclides, Reactive oxygen species

Référence

Photodiagnosis Photodyn Ther. 2023 09 30;:103816