Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.

Fiche publication

Date publication

novembre 2023

Journal

Genome biology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann , Dr YALCIN CHRISTMANN Ipek

Tous les auteurs :
Kretz PF, Wagner C, Mikhaleva A, Montillot C, Hugel S, Morella I, Kannan M, Fischer MC, Milhau M, Yalcin I, Brambilla R, Selloum M, Herault Y, Reymond A, Collins SC, Yalcin B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37968726

Résumé

Using mouse genetic studies and systematic assessments of brain neuroanatomical phenotypes, we set out to identify which of the 30 genes causes brain defects at the autism-associated 16p11.2 locus.