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Date publication

novembre 2023

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GIANGRANDE Angela , Dr CATTENOZ Pierre


Tous les auteurs :
Bazzi W, Monticelli S, Delaporte C, Riet C, Giangrande A, Cattenoz PB

Résumé

Hemocytes, the myeloid-like immune cells of , fulfill a variety of functions that are not completely understood, ranging from phagocytosis to transduction of inflammatory signals. We here show that downregulating the hemocyte-specific Glial cell deficient/Glial cell missing (Glide/Gcm) transcription factor enhances the inflammatory response to the constitutive activation of the Toll pathway. This correlates with lower levels of glutathione S-transferase, suggesting an implication of Glide/Gcm in reactive oxygen species (ROS) signaling and calling for a widespread anti-inflammatory potential of Glide/Gcm. In addition, our data reveal the expression of acetylcholine receptors in hemocytes and that Toll activation affects their expressions, disclosing a novel aspect of the inflammatory response mediated by neurotransmitters. Finally, we provide evidence for acetylcholine receptor nicotinic acetylcholine receptor alpha 6 (nAchRalpha6) regulating hemocyte proliferation in a cell autonomous fashion and for non-cell autonomous cholinergic signaling regulating the number of hemocytes. Altogether, this study provides new insights on the molecular pathways involved in the inflammatory response.

Mots clés

Drosophila, Glide/Gcm, hemocytes, inflammation, nAchRalpha6, toll

Référence

Front Immunol. 2023 11 15;14:1293766