Fiche publication
Date publication
novembre 2023
Journal
International journal of nanomedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina
,
Dr LASSALLE Henri-Pierre
Tous les auteurs :
Francois A, Dirheimer L, Chateau A, Lassalle HP, Yakavets I, Bezdetnaya L
Lien Pubmed
Résumé
The tumor microenvironment (TME) is composed of various stromal components, including immune cells such as tumor-associated macrophages (TAMs), which play a crucial role in cancer initiation and progression. TAMs can exhibit either a tumor-suppressive M1 or a tumor-promoting M2 phenotype. First, we aimed to develop a 3D human heterotypic model consisting of head and neck squamous cell carcinoma (HNSCC) cells and different subtypes of macrophages to replicate the interactions between immune cells and cancer cells. We further investigated the behavior of Foslip, a liposomal formulation of temoporfin, using a macrophage-enriched 3D model.
Mots clés
Foslip, head and neck cancer, macrophage polarization, photodynamic therapy, tumor spheroids
Référence
Int J Nanomedicine. 2023 11 9;18:6545-6562
