Fiche publication


Date publication

novembre 2023

Journal

Nephrologie & therapeutique

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DUCLOUX Didier


Tous les auteurs :
Crépin T, Lionet A, Augusto JF, Hazzan M, Garrouste C, Heng AE, Ducloux D

Résumé

For 30 years, photopheresis is used to treat graft versus host disease and heart or lung allograft rejection. In this review, we discuss the place of photopheresis in kidney transplantation both in prevention or treatment of rejection. Mechanisms of action in kidney transplantation are mainly based on results observed in graft versus host disease and in heart or lung transplantation. Photopheresis may induce innate and adaptive immunity changes with restauration of a favourable Th1/Th2 immune balance, an expansion of LT /LB reg subsets, and a local enrichment in IL-10. French national clinical and mechanistic studies are underway to define the place of photopheresis therapy in immunomodulation strategies in kidney transplantation.

Mots clés

renal transplant, photopheresis, regulatory T cell, antibody-mediated rejection

Référence

Nephrol Ther. 2023 11 2;19(6):521-531