Association of Age-Related Macular Degeneration with a Blood Biomarker of Lipopolysaccharide, a Gut Bacterial Proinflammatory Toxin.

Date publication

novembre 2023

Journal

Investigative ophthalmology & visual science

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul

Tous les auteurs :
Larsen PP, Féart C, Pais de Barros JP, Merle BMJ, Gayraud L, Delyfer MN, Korobelnik JF, Delcourt C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38032336

Résumé

Chronic inflammation, immune dysregulation, and oxidative stress are major drivers of age-related macular degeneration (AMD) pathogenesis. Lipopolysaccharide (LPS) is a potent proinflammatory toxin originating from gut bacteria. We assessed the association of a blood biomarker of LPS exposure with incident AMD.

Mots clés

Humans, Lipopolysaccharides, Gastrointestinal Microbiome, Prospective Studies, Macular Degeneration, diagnosis, Bacterial Toxins, Biomarkers

Référence

Invest Ophthalmol Vis Sci. 2023 11 1;64(14):47