Usefulness of an RNA extraction-free test for the multiplexed detection of , , and Gene Fusions in Real Life FFPE Specimens of Non-Small Cell Lung Cancers.

Fiche publication

Date publication

octobre 2023

Journal

Expert review of molecular diagnostics

Auteurs

Membres identifiés du Cancéropôle Est :
Pr VIGNAUD Jean-Michel

Tous les auteurs :
Damiola F, Alberti L, Mansuet-Lupo A, Damotte D, Hofman V, Tixier L, Penault-Llorca F, Rouquette I, Vignaud JM, Cazes A, Forest F, Begueret H, Gibault L, Badoual C, Cayre A, Taranchon-Clermont E, Duc A, Mc Leer A, Lantuejoul S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37906110

Résumé

, and rearrangements occur, respectively, in 5%, 2%, and 1% non-small cell lung cancers (NSCLC). ALK and ROS1 fusion proteins detection by immunohistochemistry (IHC) has been validated for rapid patient screening, but fusions need to be confirmed by another technique and no RET IHC test is available for clinical use.