Management of a rare mandibular giant cell tumor of bone by neoadjuvant denosumab therapy and surgery: A 4-year follow-up case report.

Date publication

octobre 2023

Journal

International journal of surgery case reports

Auteurs

Membres identifiés du Cancéropôle Est :
Pr KURTZ Jean-Emmanuel

Tous les auteurs :
Klienkoff P, Weingertner N, Geyer L, Gros CI, Kurtz JE, Bornert F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37913666

Résumé

Giant cell tumor of bone (GCTB) is a very rare tumor encountered in the jaws and its histology is quite similar to the more common giant cell granuloma of the jaws (GCGJ). These two entities can be easily confused in maxillofacial region. They are classically managed surgically, but in some localizations and in specific medical-surgical contexts, neoadjuvant therapy with denosumab may be indicated. This report tends to reinforce existing evidence in favor of the use of a neoadjuvant approach, particularly for localization of GCTB in the orofacial region.

Mots clés

Case report, Denosumab, Giant cell tumor of bone, Mandible, Oral surgery

Référence

Int J Surg Case Rep. 2023 10 30;112:108980