Solid-state NMR spectroscopy for structural studies of polypeptides and lipids in extended physiological membranes.

Date publication

mai 2023

Journal

Biochimica et biophysica acta. Biomembranes

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BECHINGER Burkhard

Tous les auteurs :
Saad A, Bechinger B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37949788

Résumé

Solid-state NMR is a quickly developing technique that allows one to obtain structural information at atomic resolution in extended lipid bilayers in a rather unique manner. Two approaches have been developed for membrane proteins and peptides namely magic angle sample spinning and the use of uniaxially oriented membrane samples. The state-of-the-art of both approaches will be introduced and the perspectives of solid-state NMR spectroscopy in the context of other structural biology techniques, pressing biomedical questions and membrane biophysics will be discussed.

Mots clés

(1)H-detected ultrafast MAS, Dynamics, Membrane proteins, Solid-state NMR, Structural biology, Supported lipid bilayers

Référence

Biochim Biophys Acta Biomembr. 2023 05 13;:184162