Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model.

Date publication

décembre 2023

Journal

Frontiers in behavioral neuroscience

Auteurs

Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann

Tous les auteurs :
Rusu A, Chevalier C, de Chaumont F, Nalesso V, Brault V, Hérault Y, Ey E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38173978

Résumé

Autism spectrum disorders affect more than 1% of the population, impairing social communication and increasing stereotyped behaviours. A micro-deletion of the 16p11.2 BP4-BP5 chromosomic region has been identified in 1% of patients also displaying intellectual disabilities. In mouse models generated to understand the mechanisms of this deletion, learning and memory deficits were pervasive in most genetic backgrounds, while social communication deficits were only detected in some models.

Mots clés

16p11.2 deletion, autism, long-term monitoring, mouse model, social behaviour, spontaneous behaviour, ultrasonic vocalisations

Référence

Front Behav Neurosci. 2023 12 19;17:1294558