Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer.

Date publication

juin 2021

Journal

ESMO open

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VIGNOT Stéphane

Tous les auteurs :
Guyot D'Asnières De Salins A, Tachon G, Cohen R, Karayan-Tapon L, Junca A, Frouin E, Godet J, Evrard C, Randrian V, Duval A, Svrcek M, Lascols O, Vignot S, Coulet F, André T, Fléjou JF, Cervera P, Tougeron D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33930657

Résumé

DNA mismatch repair system deficiency (dMMR) is found in 15% of colorectal cancers (CRCs). Two methods are used to determine dMMR, immunohistochemistry (IHC) of MMR proteins and molecular testing of microsatellite instability (MSI). Only studies with a low number of patients have reported rates of discordance between these two methods, ranging from 1% to 10%.

Mots clés

colorectal cancer, deficient mismatch repair, immunohistochemistry, microsatellite instability, molecular biology

Référence

ESMO Open. 2021 06;6(3):100120