Fiche publication
Date publication
janvier 2024
Journal
Gynecologie, obstetrique, fertilite & senologie
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LUPORSI Elisabeth
,
Pr MATHELIN Carole
Tous les auteurs :
Taris N, Luporsi E, Osada M, Thiblet M, Mathelin C
Lien Pubmed
Résumé
Breast oncology genetics emerged almost 30 years ago with the discovery of the BRCA1 and BRCA2 genes. The evolution of analytical practices has progressively allowed access to tests whose results now have a considerable impact on the management of both female and male breast cancers.The Sénologie Commission of the Collège National des Gynécologues et Obstétriciens Français (CNGOF) asked five specialists in breast surgery, oncology and oncological genetics to draw up a summary of the oncogenetic testing criteria used and the clinical implications for the female and male population of the test results, with or without an identified causal variant. In the case of proven genetic risk, surveillance, risk-reduction strategies, and the specificities of surgical and medical management (with PARP inhibitors in particular) were updated.
Mots clés
BRCA, breast canceroncog, enetics, predisposition, risk-reducing mastectomy
Référence
Gynecol Obstet Fertil Senol. 2024 01 6;:
