Fiche publication
Date publication
décembre 2014
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MELY Yves
,
Dr KLYMCHENKO Andrey
Tous les auteurs :
Niko Y, Arntz Y, Mely Y, Konishi G, Klymchenko AS
Lien Pubmed
Résumé
Stimuli-response nanoparticles have emerged as powerful tools for imaging and therapeutic applications. Ideally, they should be assembled from biodegradable materials featuring small size and cooperative response to biological stimuli that trigger particle disassembly and release of an active molecule that could be readily monitored in situ. A concept is developed that consists of organic nanoparticles, assembled from fluorescent amphiphiles and polymerized with a redox-cleavable cross-linker. We obtained 20 nm nanoparticles bearing self-quenched Nile Red dye residues, which can disassemble in living cells into highly fluorescent molecular units owing to an external or internal reductive stimulus. The obtained results pave the way to new stimuli-responsive nanomaterials for applications in background-free imaging as well as in drug delivery, as the concept can be further extended to other active molecules including drugs and to cross-linkers cleavable by other biological stimuli.
Mots clés
Cell Survival, Cross-Linking Reagents, chemistry, Fluorescence, HeLa Cells, Humans, Micelles, Nanoparticles, analysis, Optical Imaging, Oxazines, analysis, Oxidation-Reduction, Polymerization
Référence
Chemistry. 2014 Dec;20(50):16473-7
