Fiche publication
Date publication
décembre 2014
Journal
Sensors (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LEBLOIS Thérèse
Tous les auteurs :
Chopard T, Lacour V, Leblois T
Lien Pubmed
Résumé
This work demonstrates the improvement of mass detection sensitivity and time response using a simple sensor structure. Indeed, complicated technological processes leading to very brittle sensing structures are often required to reach high sensitivity when we want to detect specific molecules in biological fields. These developments constitute an obstacle to the early diagnosis of diseases. An alternative is the design of coupled structures. In this study, the device is based on the piezoelectric excitation and detection of two GaAs microstructures vibrating in antisymmetric modes. GaAs is a crystal which has the advantage to be micromachined easily using typical clean room processes. Moreover, we showed its high potential in direct biofunctionalisation for use in the biological field. A specific design of the device was performed to improve the detection at low mass and an original detection method has been developed. The principle is to exploit the variation in amplitude at the initial resonance frequency which has in the vicinity of weak added mass the greatest slope. Therefore, we get a very good resolution for an infinitely weak mass: relative voltage variation of 8%/1 fg. The analysis is based on results obtained by finite element simulation.
Mots clés
Acoustics, instrumentation, Arsenicals, chemistry, Biopolymers, analysis, Biosensing Techniques, instrumentation, Chemistry Techniques, Analytical, instrumentation, Computer-Aided Design, Equipment Design, Equipment Failure Analysis, Gallium, chemistry, Micro-Electrical-Mechanical Systems, instrumentation, Miniaturization, Molecular Weight, Oscillometry, instrumentation, Transducers
Référence
Sensors (Basel). 2014 Dec;14(12):22785-97
