Medium-chain triglyceride supplementation exacerbates peritonitis-induced septic shock in rats: role on cell membrane remodeling.

Date publication

décembre 2014

Journal

Shock (Augusta, Ga.)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie

Tous les auteurs :
Boisramé-Helms J, Said A, Burban M, Delabranche X, Stiel L, Zobairi F, Hasselmann M, Schini-Kerth V, Toti F, Meziani F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25243422

Résumé

Lipid emulsions for parenteral nutrition interfere with immunity and may alter the cell plasma membrane and microparticle release, thus modulating their biological effects. Our aim was to evaluate the effect of two lipid emulsions for parenteral nutrition containing either a mixture of long- and medium-chain triglycerides (LCTs and MCTs) or LCTs only, to assess their role on microparticle release and acute inflammation during septic shock in rats.

Mots clés

Animals, Aorta, metabolism, Cell Membrane, metabolism, Coagulants, chemistry, Electron Spin Resonance Spectroscopy, Emulsions, chemistry, Glucose, chemistry, Hemodynamics, Inflammation, Lipids, chemistry, Male, Microspheres, Myocardium, metabolism, Nitric Oxide, chemistry, Parenteral Nutrition Solutions, chemistry, Peritonitis, physiopathology, Phosphorylation, Rats, Rats, Wistar, Shock, Septic, chemically induced, Superoxides, chemistry, Time Factors, Triglycerides, adverse effects

Référence

Shock. 2014 Dec;42(6):548-53