Vacuolization of hematopoietic precursors: an enigma with multiple etiologies.

Date publication

juillet 2021

Journal

Blood

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PAGLIUCA Simona

Tous les auteurs :
Gurnari C, Pagliuca S, Durkin L, Terkawi L, Awada H, Kongkiatkamon S, Zawit M, Hsi ED, Carraway HE, Rogers HJ, Visconte V, Maciejewski JP

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33690844

Résumé

Cytoplasmic vacuoles in precursors can be seen in a number of clinical settings, including copper deficiency, zinc toxicity, alcohol abuse, antibiotic treatment, myelodysplasia, and VEXAS syndrome. Gurnari et al asked how common VEXAS syndrome is in patients whose bone marrow aspirates show this distinctive feature, finding 2 diagnoses of VEXAS among 24 cases with vacuoles.

Mots clés

Adult, Aged, Aged, 80 and over, Bone Marrow Cells, enzymology, Child, Erythroid Cells, enzymology, Female, Genes, X-Linked, Humans, Male, Middle Aged, Mutation, Myeloid Cells, enzymology, Myeloid Progenitor Cells, enzymology, Myeloproliferative Disorders, enzymology, Syndrome, Ubiquitin-Activating Enzymes, genetics, Vacuoles, enzymology

Référence

Blood. 2021 07 1;137(26):3685-3689