Comparison of the In Vitro and In Vivo Behavior of a Series of NIR-II-Emitting Aza-BODIPYs Containing Different Water-Solubilizing Groups and Their Trastuzumab Antibody Conjugates.

Date publication

février 2024

Journal

Journal of medicinal chemistry

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PAUL Catherine

Tous les auteurs :
Chazeau E, Fabre C, Privat M, Godard A, Racoeur C, Bodio E, Busser B, Wegner KD, Sancey L, Paul C, Goze C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38393818

Résumé

The development of new fluorescent organic probes effective in the NIR-II region is currently a fast-growing field and represents a challenge in the domain of medical imaging. In this study, we have designed and synthesized an innovative series of aza-boron dipyrromethenes emitting in the NIR-II region. We have investigated the effect of different water-solubilizing groups not only on the photophysical properties of the compounds but also on their in vitro and in vivo performance after bioconjugation to the antibody trastuzumab. Remarkably, we discovered that the most lipophilic compound unexpectedly displayed the most favorable in vivo properties after bioconjugation. This underlines the profound influence that the fluorophore functionalization approach can have on the efficiency of the resulting imaging agent.

Référence

J Med Chem. 2024 02 23;: