Fiche publication
Date publication
mars 2024
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HAFFEN Emmanuel
,
Dr HICHAMI Aziz
Tous les auteurs :
Jantzen L, Dumontoy S, Ramadan B, Houdayer C, Haffen E, Hichami A, Khan NA, Van Waes V, Cabeza L
Lien Pubmed
Résumé
We investigated whether linoleic acid (LA) supplementation could modulate emotional behavior and microglia-related neuroinflammation. For that, male mice of C57BL/6J genetic background fed either a high-fat diet (HFD) or a standard diet (STD) for 12 weeks, were treated with a vehicle or LA solution for 5 weeks before being evaluated for emotional behavior using a battery of behavioral tests. The animals were subsequently sacrificed and their brains collected and processed for immunofluorescence staining, targeting microglia-specific calcium-binding proteins (IBA-1). Neuroinflammation severity was assessed in multiple hypothalamic, cortical and subcortical brain regions. We show an anxio-depressive-like effect of sustained HFD feeding that was neither alleviated nor worsened with LA supplementation. However, increased IBA-1 expression and microgliosis in the HFD group were largely attenuated by LA supplementation. These observations demonstrate that the anti-neuroinflammatory properties of LA are not restricted to hypothalamic areas but are also evident at the cortical and subcortical levels. This study discloses that neuroinflammation plays a role in the genesis of neuropsychiatric disorders in the context of obesity, and that LA supplementation is a useful dietary strategy to alleviate the impact of obesity-related neuroinflammation.
Mots clés
Mice, Male, Animals, Microglia, Linoleic Acid, pharmacology, Neuroinflammatory Diseases, Mice, Inbred C57BL, Obesity, etiology, Diet, High-Fat, adverse effects, Dietary Supplements
Référence
Sci Rep. 2024 03 19;14(1):6644
