Fiche publication
Date publication
février 2024
Journal
European journal of case reports in internal medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NICOLAE Alina
Tous les auteurs :
Pasquer R, Dieudonné Y, Decours P, Hinschberger O, Nicolae A, Martinot M
Lien Pubmed
Résumé
Castleman's disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In this study, we present a case of a 53-year-old patient with controlled HIV infection who presented with fever, lymphadenopathy, severe anaemia, and thrombocytopenia. After a series of tests, the diagnosis was concurrent human herpesvirus 8 (HHV8)-related multicentric CD (MCD) and TTP. Only four male patients were previously reported having this association, with HHV8 present in four and HIV in three patients, suggesting that coinfection with HHV8 and HIV is a pivotal factor in MCD with TTP occurrence.
Mots clés
Castleman’s disease, HHV8, HIV, autoimmune hypoglycaemia, thrombotic thrombocytopenic purpura
Référence
Eur J Case Rep Intern Med. 2024 02 28;11(3):004361
