DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection.

Fiche publication

Date publication

mars 2024

Journal

Virology journal

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PFEFFER Sébastien , Mr HAMMANN Philippe

Tous les auteurs :
Messmer M, Pierson L, Pasquier C, Djordjevic N, Chicher J, Hammann P, Pfeffer S, Girardi E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38553727

Résumé

RNA helicases are emerging as key factors regulating host-virus interactions. The DEAD-box ATP-dependent RNA helicase DDX5, which plays an important role in many aspects of cellular RNA biology, was also found to either promote or inhibit viral replication upon infection with several RNA viruses. Here, our aim is to examine the impact of DDX5 on Sindbis virus (SINV) infection.