Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet.

Fiche publication

Date publication

mars 2024

Journal

Frontiers in nutrition

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GENY Bernard , Dr MALLARD Joris , Dr DUTEIL Delphine , Dr ZOLL Joffrey

Tous les auteurs :
Charlot A, Bringolf A, Mallard J, Charles AL, Niederhoffer N, Duteil D, Pagano AF, Geny B, Zoll J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38571752

Résumé

Obesity and metabolic complications, such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), are one of the greatest public health challenges of the 21st century. The major role of high sugar and carbohydrate consumption rather than caloric intake in obesity and NAFLD pathophysiology remains a subject of debate. A low-carbohydrate but high-fat diet (LCHFD) has shown promising results in obesity management, but its effects in preventing NAFLD need to be detailed. This study aims to compare the effects of a LCHFD with a high-fat high-sugar obesogenic Western diet (WD) on the progression of obesity, type 2 diabetes, and nonalcoholic fatty liver disease.