Fiche publication
Date publication
avril 2024
Journal
Matrix biology : journal of the International Society for Matrix Biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr OREND Gertraud
Tous les auteurs :
Dhaouadi S, Bouhaouala-Zahar B, Orend G
Lien Pubmed
Résumé
Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.
Mots clés
Tenascin-C, antibody, aptamer, biomarker, cancer, diagnostic application, extracellular matrix, inflammation, nanobody, peptide, therapeutic approach, tumor, tumor immunity
Référence
Matrix Biol. 2024 04 18;:
