Fiche publication
Date publication
mai 2024
Journal
Pediatric blood & cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LACOUR Brigitte
Tous les auteurs :
Castex MP, Stefanowicz J, Clement L, Węcławek-Tompol J, Hameury F, Fresneau B, Irtan S, Brunac AC, Januszkiewicz-Lewandowska D, Lacour B, Faure-Conter C, Orbach D
Lien Pubmed
Résumé
Choriocarcinoma in neonates and infants (N-CC) is an extremely rare, but aggressive cancer, frequently observed with concomitant maternal disease. A retrospective, bi-national study of patients treated in France and Poland for infantile choriocarcinoma analysed eight cases of N-CC, median age of 6 weeks. All tumours were diffuse. Six patients received a platinum-based regimen, and five had delayed surgery on residual distant tumour sites. At the end of follow-up, four patients were in complete remission and four had died of the disease. In all but two cases, mothers had simultaneous metastatic choriocarcinoma. Even if the outcome remains poor, patients could be cured with multimodal therapy.
Mots clés
chemotherapy, choriocarcinoma, maternofoetal transmission, neonatal tumour
Référence
Pediatr Blood Cancer. 2024 05 30;:e31124
