VEGF-R2/CAV-1 Interaction Induced by Resveratrol/Eicosapentaenoic Acid/Docosahexaenoic Acid-Enriched Formulation through Functional Detergent-Resistant Membranes Is Associated with Decreased VEGF-A Release in ARPE-19 Cells.

Fiche publication

Date publication

mai 2024

Journal

Molecular nutrition & food research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DELMAS Dominique , Dr HERMETET François , Dr PAIS DE BARROS Jean-Paul , Dr AIRES Virginie

Tous les auteurs :
Perus M, Courtaut F, Pais de Barros JP, Aires V, Hermetet F, Delmas D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38763919

Résumé

Omega-3 fatty acids (O3FAs) and resveratrol (RSV) are known to be beneficial for certain eye diseases, such as age-related macular degeneration (AMD). Neovascular AMD is characterized by abnormal blood vessel formation due to the excessive synthesis of vascular endothelial growth factor (VEGF) by retinal pigment epithelium (RPE) cells. The study investigates whether a formulation based on eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and RSV is capable of counteracting VEGF-A secretion, and elucidates the molecular mechanism.