From the design of innovative Ti-Pt heterometallic complexes to the development of highly anti-proliferative water-soluble cationic titanocenes.

Fiche publication

Date publication

mai 2024

Journal

Chembiochem : a European journal of chemical biology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali , Dr DUBREZ Laurence , Pr PAUL Catherine

Tous les auteurs :
Trommenschlager A, Mabrouk N, Racoeur C, Godard A, Balan C, Dubrez L, Bettaieb A, Husson J, Le Gendre P, Paul C, Bodio E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38749920

Résumé

Two innovative early/late Ti-Pt-heterobimetallic complexes were synthesized, characterized, and screened in cell-based assays using several human (SW480 and MDA-MB-231) and murine cancer cell lines (CT26 and EMT6) as well as a non-cancerous cell line (HMEC). The combination of the two metals - titanium(IV) and platinum (IV) - in a single molecule led to a synergistic biological activity (higher anti-proliferative properties than a mixture of each of the corresponding monometallic complexes). This study also investigated the benefits of associating a metal-free terpyridine moiety (with intrinsic biological activity) with a water-soluble titanocene fragment. The present work reveals that these combinations results in water-soluble titanocene compounds displaying an anti-proliferative activity down to the submicromolar level. One of these complexes induced an antitumor effect in vivo in CT26 tumor bearing BALB/C mice. The terpyridine moiety was also used to track the complex in vitro by multiphoton microscopy imaging.