Hypertriglyceridemia Results From an Impaired Catabolism of Triglyceride-Rich Lipoproteins in -Related Lipodystrophy.

Fiche publication

Date publication

juin 2024

Journal

Arteriosclerosis, thrombosis, and vascular biology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DUVILLARD Laurence , Pr VERGES Bruno

Tous les auteurs :
Vergès B, Vantyghem MC, Reznik Y, Duvillard L, Rouland A, Capel E, Vigouroux C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38899472

Résumé

Pathogenic variants in -encoding PLIN1 (perilipin-1) are responsible for an autosomal dominant form of familial partial lipodystrophy (FPL) associated with severe insulin resistance, hepatic steatosis, and important hypertriglyceridemia. This study aims to decipher the mechanisms of hypertriglyceridemia associated with -related FPL.