Fiche publication
Date publication
juin 2024
Journal
World journal of surgical oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARESCAUX Jacques
,
Pr MUTTER Didier
,
Pr AKLADIOS Chérif
Tous les auteurs :
Pavone M, Waeldin L, Seeliger B, Bizzarri N, Mutter D, Jarnet D, Forgione A, Georges N, Akladios C, Scambia G, Marescaux J, Lecointre L, Querleu D
Lien Pubmed
Résumé
Radio(chemo)therapy is often required in pelvic malignancies (cancer of the anus, rectum, cervix). Direct irradiation adversely affects ovarian and endometrial function, compromising the fertility of women. While ovarian transposition is an established method to move the ovaries away from the radiation field, surgical procedures to displace the uterus are investigational. This study demonstrates the surgical options for uterine displacement in relation to the radiation dose received. METHODS: The uterine displacement techniques were carried out sequentially in a human female cadaver to demonstrate each procedure step by step and assess the uterine positions with dosimetric CT scans in a hybrid operating room. Two treatment plans (anal and rectal cancer) were simulated on each of the four dosimetric scans (1. anatomical position, 2. uterine suspension of the round ligaments to the abdominal wall 3. ventrofixation of the uterine fundus at the umbilical level, 4. uterine transposition). Treatments were planned on Eclipse® System (Varian Medical Systems®,USA) using Volumetric Modulated Arc Therapy. Data about maximum (Dmax) and mean (Dmean) radiation dose received and the volume receiving 14 Gy (V14Gy) were collected.
Mots clés
Humans, Female, Cadaver, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, methods, Fertility Preservation, methods, Uterus, radiation effects, Pelvic Neoplasms, radiotherapy, Radiotherapy, Intensity-Modulated, methods, Organ Sparing Treatments, methods, Organs at Risk, radiation effects, Prognosis, Radiometry, methods
Référence
World J Surg Oncol. 2024 06 3;22(1):147
