Fiche publication
Date publication
novembre 2014
Journal
Trials
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BINQUET Christine
Tous les auteurs :
Bruyère R, Soudry-Faure A, Capellier G, Binquet C, Nadji A, Torner S, Blasco G, Yannaraki M, Barbar SD, Quenot JP
Lien Pubmed
Résumé
The incidence of acute kidney injury (AKI) is estimated at 10 to 20% in patients admitted to intensive care units (ICU) and often requires renal replacement therapy (RRT). ICU mortality in AKI patients can exceed 50%. Venous catheters are the preferred vascular access method for AKI patients requiring RRT, but carry a risk of catheter thrombosis or infection. Catheter lock solutions are commonly used to prevent such complications. Heparin and citrate locks are both widely used for tunneled, long-term catheters, but few studies have compared citrate versus heparin for patients with short-term, non-tunneled catheters. We aim to compare citrate 4% catheter lock solution versus heparin in terms of event-free survival of the first non-tunneled hemodialysis catheter inserted in ICU patients with AKI requiring RRT. Secondary objectives are the rate of fibrinolysis, incidence of catheter thrombosis and catheter-related infection per 1,000 catheter days, length of stay in ICU and in-hospital and 28-day mortality.
Mots clés
Acute Kidney Injury, diagnosis, Anticoagulants, adverse effects, Catheter Obstruction, etiology, Catheterization, Central Venous, adverse effects, Central Venous Catheters, Citrates, adverse effects, Clinical Protocols, Double-Blind Method, Equipment Design, France, Heparin, adverse effects, Hospitals, University, Humans, Intensive Care Units, Prospective Studies, Renal Dialysis, adverse effects, Research Design, Time Factors, Treatment Outcome, Upper Extremity Deep Vein Thrombosis, diagnosis
Référence
Trials. 2014 Nov;15:449
