Short-Term Postnatal Overfeeding Induces Long-Lasting Cardiometabolic Syndrome in Mature and Old Mice Associated with Increased Sensitivity to Myocardial Infarction.

Date publication

juin 2024

Journal

Molecular nutrition & food research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr VERGELY Catherine

Tous les auteurs :
Rigal E, Josse M, Greco C, Rosenblatt N, Rochette L, Guenancia C, Vergely C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/38937861

Résumé

Perinatal nutritional disturbances may "program" an increased cardio-metabolic risk in adulthood; however, few experimental studies have explored their effects on mature and/or old animal. This study aims to investigate the influence of postnatal overfeeding (PNOF) on cardiac function, sensitivity to ischemia-reperfusion (I-R) injury in vivo, glucose metabolism, and metabolic profile of pericardial adipose tissue (PAT) in young (4 months), adult (6 months), old (12 months), and very old (18 months) male mice.

Mots clés

insulin resistance, ischemia‐reperfusion injury, metabolic syndrome, pericardial adipose tissue, postnatal programming

Référence

Mol Nutr Food Res. 2024 06 27;:e2400136