Fiche publication
Date publication
décembre 2024
Journal
Nucleus (Austin, Tex.)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SUMARA Izabela
Tous les auteurs :
Lin J, Sumara I
Lien Pubmed
Résumé
Nucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures, suggesting potential non-transport-related roles. This review consolidates findings on cytoplasmic nucleoporin assemblies across different states, including normal physiological conditions, stress, and pathology, exploring their structural organization, formation dynamics, and functional implications. We summarize the current knowledge and the latest concepts on the regulation of nucleoporin homeostasis, aiming to enhance our understanding of their unexpected roles in physiological and pathological processes.
Mots clés
Annulate Lamellae, Nuclear Pore Complex, cytoplasmic nucleoporin foci, homeostasis, nucleoporins, pathology
Référence
Nucleus. 2024 12;15(1):2387534
