Cooperation Between Platelet β1 and β3 Integrins in the Arrest of Bleeding Under Inflammatory Conditions in Mice.

Fiche publication

Date publication

août 2024

Journal

Arteriosclerosis, thrombosis, and vascular biology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MANGIN Pierre

Tous les auteurs :
Janus-Bell E, Receveur N, Mercier L, Mouriaux C, Magnenat S, Reiser J, Lanza F, Hechler B, Ho-Tin-Noé B, Mangin PH

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39145395

Résumé

Platelets prevent bleeding in a variety of inflammatory settings, the adhesion receptors and activation pathways involved being highly context-dependent and functionally redundant. In some situations, platelets recruited to inflammatory sites act independently of aggregation. The mechanisms underlying stable platelet adhesion in inflamed microvessels remain incompletely understood, in particular, whether and if so, how β1 and β3 integrins are involved.