Fiche publication
Date publication
août 2024
Journal
Cell death & disease
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François
,
Dr BRUCHARD Mélanie
Tous les auteurs :
Coënon L, Geindreau M, Ghiringhelli F, Villalba M, Bruchard M
Lien Pubmed
Résumé
Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line defenders in the anti-tumor response. To prevent tumor development, NK cells are searching for abnormal cells within the body and appear to be key players in immunosurveillance. Upon recognition of abnormal cells, NK cells will become activated to destroy them. In order to fulfill their anti-tumoral function, they rely on the secretion of lytic granules, expression of death receptors and production of cytokines. Additionally, NK cells interact with other cells in the tumor microenvironment. In this review, we will first focus on NK cells' activation and cytotoxicity mechanisms as well as NK cells behavior during serial killing. Lastly, we will review NK cells' crosstalk with the other immune cells present in the tumor microenvironment.
Mots clés
Humans, Killer Cells, Natural, immunology, Neoplasms, immunology, Tumor Microenvironment, immunology, Animals, Cytotoxicity, Immunologic
Référence
Cell Death Dis. 2024 08 23;15(8):614
