Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.

Fiche publication

Date publication

septembre 2024

Journal

BMC biology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BRONNER Christian , Dr HAMICHE Ali

Tous les auteurs :
Ouararhni K, Mietton F, Sabir JSM, Ibrahim A, Molla A, Albheyri RS, Zari AT, Bahieldin A, Menoni H, Bronner C, Dimitrov S, Hamiche A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39218869

Résumé

The histone variant macroH2A (mH2A), the most deviant variant, is about threefold larger than the conventional histone H2A and consists of a histone H2A-like domain fused to a large Non-Histone Region responsible for recruiting PARP-1 to chromatin. The available data suggest that the histone variant mH2A participates in the regulation of transcription, maintenance of heterochromatin, NAD metabolism, and double-strand DNA repair.