Fiche publication
Date publication
décembre 2016
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CHAN-SENG Delphine
Tous les auteurs :
Fiers G, Chouikhi D, Oswald L, Al Ouahabi A, Chan-Seng D, Charles L, Lutz JF
Lien Pubmed
Résumé
Sequence-defined peptide triazole nucleic acids (PTzNA) were synthesized by means of a solid-phase orthogonal "AB+CD" iterative strategy. In this approach, AB and CD building blocks containing carboxylic acid (A), azide (B), alkyne (C), and primary amine (D) functions are assembled together by successive copper-catalyzed azide-alkyne cycloaddition (CuAAC) and acid-amine coupling steps. Different PTzNA genetic sequences were prepared using a library of eight building blocks (i.e., four AB and four CD building blocks).
Mots clés
iterative chemistry, nucleic acids, orthogonal synthesis, sequence-controlled polymers, solid-phase synthesis
Référence
Chemistry. 2016 12 12;22(50):17945-17948
