Fiche publication
Date publication
septembre 2024
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Dr RETIF Paul
Tous les auteurs :
Popotte C, Berthel É, Letellier R, Rancati T, Orlandi E, Munier M, Retif P, Pereira S
Lien Pubmed
Résumé
In head and neck squamous cell carcinoma (HNSCC), early complications of the radiotherapy (RT) are observed from the beginning of the treatment to a few months after its end. During external radiotherapy treatment, several patient-dependent parameters can cause a modification of the dose distribution compared to the planned distribution due to variation in patient positioning, anatomy, or intra-fractional movements for example. To verify these parameters during treatment sessions, one of the most commonly used solutions is the cone-beam computed tomography (CBCT). Nowadays, the use of CBCT may constitutes a significant part of the total dose at the end of treatment (up to 10 cGy per session) and more often the volume irradiated by imaging is larger than the one irradiated by the treatment, leading to unintentional irradiation of nearby organs. In this study, we asked whether the imaging low dose added to a following fraction dose (2Gy) may affect the biological response in terms of DNA repair.
Mots clés
Cancer, DNA repair, Dosimètre à scintillation, Fibre optique, Optical fiber, Radiosensibilité, Radiosensitivity, Radiotherapy, Radiothérapie, Réparation de l’ADN, Scintillating dosimetry, pATM
Référence
Cancer Radiother. 2024 09 17;:
