Response to chemotherapy is not related to chromosome instability in synovial sarcoma.

Date publication

novembre 2014

Journal

Annals of oncology : official journal of the European Society for Medical Oncology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr AVEROUS Gerlinde

Tous les auteurs :
Chakiba C, Lagarde P, Pissaloux D, Neuville A, Brulard C, Pérot G, Coindre JM, Terrier P, Ranchere-Vince D, Ferrari A, Collini P, Suurmeijer AJ, Blay JY, Terrisse SA, Piperno-Neumann S, Averous G, Bui B, Orbach D, Italiano A, Chibon F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25070544

Résumé

Synovial sarcoma (SS) is an aggressive soft-tissue tumor. Despite being considered as a chemosensitive disease, the real impact of perioperative chemotherapy on metastasis-free survival (MFS) is controversial. We have shown that metastatic relapse of SS is strongly associated with genomic complexity. There are no data regarding the potential correlation between genomic complexity and response to chemotherapy.

Mots clés

Adolescent, Adult, Aged, Child, Child, Preschool, Chromosomal Instability, genetics, Female, Genome, Human, Humans, Ifosfamide, administration & dosage, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Recurrence, Local, drug therapy, Prognosis, Sarcoma, Synovial, drug therapy

Référence

Ann. Oncol.. 2014 Nov;25(11):2267-71