Fiche publication
Date publication
septembre 2024
Journal
Photodiagnosis and photodynamic therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina
,
Pr DOLIVET Gilles
,
Pr MARCHAL Frédéric
,
Dr CORTESE Sophie
Tous les auteurs :
Dirheimer L, Pons T, François A, Lamy L, Marchal F, Gilles D, Sophie C, Bezdetnaya L
Lien Pubmed
Résumé
Oral squamous cell carcinoma (OSCC) treatment mainly relies on surgery. The status of surgical margin is a major prognostic factor for patients as positive margins are associated with lower survival. However, the anatomical particularities of this area complicate margin establishment. Fluorescence guided surgery (FGS) could be employed as an intraoperative technique to improve tumor resection and margin investigation. Quantum dots (QDs) serve as ideal contrast agents in this technique due to their brightness and stability. Since αVβ6 integrin is overexpressed in OSCC, coupling QDs with A20FMDV2 peptide (QDs-A20) targeting the αVβ6 integrin constitute a real opportunity. This study investigates the accumulation of QDs-A20 in 2D and 3D tongue cancer models, as well as QDs coupled to a scrambled version of this peptide (QDs-Scr) or without peptide (QDs-SPP), for imaging purposes.
Mots clés
Fluorescence imaging, Head and neck cancer, Oral cancer, Quantum Dots (QDs), Spheroid, Tongue cancer, αVβ6 Integrin
Référence
Photodiagnosis Photodyn Ther. 2024 09 25;:104337
