Size and crystallinity effects on enzymatic activity and anti-inflammatory properties of cysteine-assisted Prussian blue nanozymes.

Fiche publication

Date publication

octobre 2024

Journal

Journal of colloid and interface science

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MENARD-MOYON Cécilia , Dr BIANCO Alberto

Tous les auteurs :
He Y, Bianco A, Ménard-Moyon C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39413589

Résumé

Prussian blue nanoparticles (PB NPs) exhibit multiple enzymatic activities, such as superoxide dismutase-like, catalase-like, and peroxidase-like activities, which enable them to effectively scavenge reactive oxygen species (ROS) and demonstrate anti-inflammatory effects. To further enhance the enzymatic activity of PB NPs, it is crucial to explore the relationship between their physicochemical properties, such as size and crystallinity, and their enzymatic performance. In this study, PB NPs were synthesized using different pH levels and varying concentrations of cysteine (Cys) as a stabilizer. As the size decreases, crystallinity is gradually reduced, and defects increase. Cys-PB NPs with a smaller size and lower crystallinity exhibited high peroxidase-like activity, effectively reducing inflammation and scavenging intracellular ROS in vitro. Additionally, the stability of Cys-PB NPs plays a critical role in their anti-inflammatory properties, with higher stability favouring anti-inflammatory effect.