Fiche publication
Date publication
octobre 2024
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ANTONI Delphine
,
Pr TRUC Gilles
,
Dr LE FEVRE Clara
Tous les auteurs :
Biau J, Guillemin F, Ginzac A, Villa J, Truc G, Antoni D, Le Fèvre C, Thillays F
Lien Pubmed
Résumé
Traditionally, postoperative whole-brain radiation therapy (WBRT) has been used for resected brain metastases, reducing local and intracerebral relapses. However, WBRT is associated with cognitive deterioration. Postoperative stereotactic radiotherapy (SRT) has emerged due to its neurocognitive preservation benefits. Despite its advantages, postoperative SRT has several drawbacks, including difficulties in target volume delineation, increased risk of radionecrosis (RN) and leptomeningeal disease (LMD), and prolonged treatment duration. Preoperative SRT has been proposed as a potential alternative, offering promising results in retrospective studies. Retrospective studies have suggested that preoperative SRT could achieve high local control rates with fewer LMD and RN rates compared to postoperative SRT. However, preoperative SRT is primarily based on retrospective data, and no phase 2/3 trials have been published to date. Ongoing clinical trials are expected to provide further insights into the efficacy and safety of preoperative SRT, addressing key questions regarding fractionation, dose, and timing relative to surgery.
Mots clés
Brain metastases, Métastases cérébrales, Preoperative, Préopératoire, Radiothérapie stéréotaxique, Stereotactic radiotherapy
Référence
Cancer Radiother. 2024 10 1;:
