Fiche publication
Date publication
août 2024
Journal
Ophthalmology science
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul
Tous les auteurs :
Larsen PP, Féart C, Pais de Barros JP, Gayraud L, Delyfer MN, Korobelnik JF, Schweitzer C, Delcourt C
Lien Pubmed
Résumé
Lipopolysaccharide (LPS)-type endotoxins are naturally found in the gut microbiota and there is emerging evidence linking gut microbiota and neuroinflammation leading to retinal neurodegeneration. Thinning of the retinal nerve fiber layer (RNFL) is a biomarker of retinal neurodegeneration, and a hallmark of glaucoma, the second leading cause of blindness worldwide. We assessed the association of a blood biomarker of LPS with peripapillary RNFL thickness (RNFLT) and its longitudinal evolution up to 11 years.
Mots clés
Clinical (human) or epidemiologic studies: risk factor assessment, LPS, Microbiota, Systemic inflammation
Référence
Ophthalmol Sci. 2024 08 28;5(1):100610
