Fiche publication
Date publication
mars 2024
Journal
Juntendo Iji zasshi = Juntendo medical journal
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MAUVIEUX Laurent
Tous les auteurs :
Helms J, Meziani F, Mauvieux L, Iba T
Lien Pubmed
Résumé
Neutrophils serve as the frontline defenders in the host's response to infections. However, the available methods for assessing the activated status of neutrophils are still limited. The immature cells that appear during sepsis are large with complex cytoplasmic components and rich nucleic acids, making them diagnosable by cell population data analysis using the automated cell counter. The changes are expressed as increased forward scattered light, side fluorescence light, and side fluorescence distribution width. Additionally, changes in side fluorescence light may indicate the neutrophil extracellular trap formation and can be useful for the diagnosis of sepsis-associated disseminated intravascular coagulation.
Mots clés
cell count, cell death, neutrophil, neutrophil extracellular traps, sepsis
Référence
Juntendo Iji Zasshi. 2024 03 18;70(2):114-117
