Fiche publication
Date publication
octobre 2014
Journal
Journal of materials chemistry. B
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HOEFFEL Christine
Tous les auteurs :
Callewaert M, Roullin VG, Cadiou C, Millart E, Van Gulik L, Andry MC, Portefaix C, Hoeffel C, Laurent S, Elst LV, Muller R, Molinari M, Chuburu F
Lien Pubmed
Résumé
A series of hydrogel nanoparticles incorporating MRI contrast agents (GdDOTP and MS325) as potential cross-linkers were elaborated by an easy and robust ionotropic gelation process. By this process, high Gd loadings were obtained (between 1.8 and 14.5 × 10 Gd centres per NP). By tuning the cross-linker ionization degree and the nature of the polymer matrix it was possible to boost the r relaxivity per Gd centre up to 22-fold. The greatest gains in relaxivity were observed for nanogels for which the polymer matrix was constituted of chitosan and hyaluronan. Relaxivities per Gd centre as high as 100 s mM at 30 MHz can be reached, which highlighted the fact that molecular motion of the Gd chelate was effectively restricted and water access to the inner core of these nanogels was not limited.
Référence
J Mater Chem B. 2014 Oct 7;2(37):6397-6405
