Fiche publication


Date publication

octobre 2024

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GROS Frédéric


Tous les auteurs :
Le Tallec E, Bellamri N, Lelong M, Morzadec C, Frenger Q, Ballerie A, Cazalets C, Lescoat A, Gros F, Lecureur V

Résumé

Systemic sclerosis (SSc) is an autoimmune disease characterized by antinuclear antibody production, which has been linked to an excess of apoptotic cells, normally eliminated by macrophages through efferocytosis. Additionally, circulating levels of CXCL4, a novel SSc biomarker, correlate with more severe fibrotic manifestations of the disease. Considering the defective efferocytosis of macrophages in SSc and the CXCL4-related M4 macrophage phenotype, we hypothesized that CXCL4 could be involved in the alteration of phagocytic functions of macrophages in SSc, including LC3-associated phagocytosis (LAP), another phagocytic process requiring autophagy proteins and contributing to immune silencing.

Mots clés

CXCL4, efferocytosis, fibrosis, macrophage, phagocytosis, systemic sclerosis

Référence

Front Immunol. 2024 10 11;15:1468821