Fiche publication
Date publication
novembre 2024
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KREZEL Wojciech
Tous les auteurs :
Kittke V, Zhao C, Lam DD, Harrer P, Krezel W, Schormair B, Oexle K, Winkelmann J
Lien Pubmed
Résumé
MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for developmental processes in a wide range of tissues, including the brain. They can execute redundant functions when co-expressed in the same cell types, but their roles during early stages of neural differentiation have not been systematically compared. By separate knockout and overexpression of MEIS1 and MEIS2 in human neural stem cells, we find they control specific sets of target genes, associated with distinct biological processes. Integration of DNA binding sites with differential transcriptomics implicates MEIS1 to co-regulate gene expression by interaction with transcription factors of the SOX and FOX families. MEIS1 harbors the strongest risk factor for restless legs syndrome (RLS). Our data suggest that MEIS1 can directly regulate the RLS-associated genes NTNG1, MDGA1 and DACH1, constituting new approaches to study the elusive pathomechanism or RLS.
Mots clés
Humans, Neural Stem Cells, metabolism, Myeloid Ecotropic Viral Integration Site 1 Protein, metabolism, Homeodomain Proteins, metabolism, Restless Legs Syndrome, genetics, Transcription Factors, metabolism, Eye Proteins, metabolism, Gene Expression Regulation, Cell Differentiation
Référence
Sci Rep. 2024 11 22;14(1):28986
