Fiche publication
Date publication
novembre 2024
Journal
Immunological investigations
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FOURNEL Sylvie
,
Dr FRISCH Benoit
,
Dr HEURTAULT Béatrice
Tous les auteurs :
Seguin C, Seif M, Jacoberger-Foissac C, Gentine P, Wantz M, Frisch B, Heurtault B, Fournel S
Lien Pubmed
Résumé
Like innate cells, B cells also express Pattern Recognition Receptors (PRRs) to detect danger signal such as tissue damage or pathogen intrusion. Production of specific antibodies by plasma cells results from the activation and differentiation of B cells following three signals: (i) antigen recognition by B Cell Receptors, (ii) recognition of danger and (iii) T-cell help. However, it is unclear whether T-cell help is dispensable for B cell activation and differentiation or not. Few studies have investigated the role of cytosolic PRRs such as NOD1 in B cell differentiation.
Mots clés
B-cell, CD23, NOD1 agonist, T-independent activation, plasma cells
Référence
Immunol Invest. 2024 11 19;:1-15
