Fiche publication
Date publication
novembre 2024
Journal
Natural product reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr WEISSMAN Kira
Tous les auteurs :
François RMM, Massicard JM, Weissman KJ
Lien Pubmed
Résumé
Covering: up to 2024.For many years, the value of complex polyketides lay in their medical properties, including their antibiotic and antifungal activities, with little consideration paid to their native functions. However, more recent evidence gathered from the study of inter-organismal interactions has revealed the influence of these metabolites upon the ecological adaptation and distribution of their hosts, as well as their modes of communication. The increasing number of sequenced genomes and associated transcriptomes has also unveiled the widespread occurrence of the underlying biosynthetic enzymes across all kingdoms of life, and the important contributions they make to physiological events specific to each organism. This review depicts the diversity of roles fulfilled by type I polyketides, particularly in light of studies carried out during the last decade, providing an initial overall picture of their diverse functions.
Référence
Nat Prod Rep. 2024 11 18;:
