Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring.

Fiche publication

Date publication

novembre 2024

Journal

Journal of neuroinflammation

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul

Tous les auteurs :
Tarhini S, Crespo-Quiles C, Buhler E, Pineau L, Pallesi-Pocachard E, Villain S, Saha S, Silvagnoli L, Stamminger T, Luche H, Cardoso C, Pais de Barros JP, Burnashev N, Szepetowski P, Bauer S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39548550

Résumé

Congenital cytomegalovirus (CMV) infections represent one leading cause of human neurodevelopmental disorders. Despite their high prevalence and severity, no satisfactory therapy is available and pathophysiology remains elusive. The pathogenic involvement of immune processes occurring in infected developing brains has been increasingly documented. Here, we have used our previously validated rat model of CMV infection of the fetal brain in utero to test whether the maternal administration of four different drugs with immunomodulatory properties would have an impact on the detrimental postnatal outcome of CMV infection.