Radiation therapy in functioning and no functioning pituitary neuroendocrine tumor: systematic review of the recent literature after 2011.

Fiche publication

Date publication

novembre 2024

Journal

Frontiers in endocrinology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NOEL Georges , Dr CEBULA Hélène

Tous les auteurs :
Hemaidia RM, Cebula H, Goichot B, Noel G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39600946

Résumé

Neuroendocrine pituitary tumor, a benign cells proliferation, can cause significant morbidity due to its local invasiveness and secretory properties. Historically, radiotherapy has been employed as a second or third-line treatment option, with studies dating back to the mid-20th century. However, advancements in radiotherapy techniques, such as intensity-modulated radiation therapy (IMRT), stereotactic radiosurgery, and proton therapy, have revolutionized treatment approaches. This review aims to critically evaluate the recent literature (2011-2022) on the use of radiotherapy in both functioning and nonfunctioning neuroendocrine pituitary tumor. We employed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology to systematically analyze 52 articles, focusing on local and hormonal control, radiotherapy protocols, and treatment-related side effects.