Fiche publication
Date publication
décembre 2024
Journal
Bioinformatics advances
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DEVIGNES Marie-Dominique
Tous les auteurs :
Amaya-Ramirez D, Devriese M, Lhotte R, Usureau C, Smaïl-Tabbone M, Taupin JL, Devignes MD
Lien Pubmed
Résumé
The human leukocyte antigen (HLA) system is the main cause of organ transplant loss through the recognition of HLAs present on the graft by donor-specific antibodies raised by the recipient. It is therefore of key importance to identify all potentially immunogenic B-cell epitopes on HLAs in order to refine organ allocation. Such HLAs epitopes are currently characterized by the presence of polymorphic residues called "eplets". However, many polymorphic positions in HLAs sequences are not yet experimentally confirmed as eplets associated with a HLA epitope. Moreover, structural studies of these epitopes only consider 3D static structures.
Référence
Bioinform Adv. 2024 12 5;4(1):vbae186
